ZAP Surgical to Unveil ZAP-X® Radiosurgery Platform at ESTRO 2025
ZAP Surgical Systems, Inc., a global leader in non-invasive brain surgery technology, has announced its first-time participation at the 2025 ESTRO (European Society for Radiotherapy and Oncology) annual scientific meeting, which will take place from May 2–5 in Vienna, Austria. ZAP will showcase its groundbreaking ZAP-X® Gyroscopic Radiosurgery® platform, along with the newly introduced ZAP-Axon® Radiosurgery Planning System*.
Marking its debut at ESTRO, ZAP aims to give attendees a hands-on look at the future of cranial radiosurgery. The company will present a full-scale model of the ZAP-X system—an innovative solution designed specifically for treating brain tumors using non-invasive, high-precision radiation. Unlike traditional radiosurgery systems, ZAP-X eliminates the need for costly radiation-shielded rooms and avoids the use of outdated Cobalt-60 radioactive sources.
Visitors to the ZAP Surgical booth will also have the chance to interact with demo stations of ZAP-Axon®, a newly announced radiosurgery planning software. This advanced system provides a user-friendly interface and cutting-edge tools designed to streamline and elevate the treatment planning process for stereotactic radiosurgery (SRS).
“We’re thrilled to bring ZAP-X to the ESTRO community for the very first time,” said Dr. John R. Adler, founder and CEO of ZAP Surgical Systems, and Emeritus Dorothy & TK Chan Professor of Neurosurgery and Radiation Oncology at Stanford University. “ZAP-X represents a new generation of radiosurgery technology. By integrating gyroscopic beam delivery, a vault-free design, and a modern linear accelerator, we’re enabling greater access to high-end radiosurgical care around the world.”
What sets ZAP-X apart is its unique gyroscopic motion. The system can deliver radiation beams from thousands of angles, using a larger spherical workspace than traditional devices. This approach significantly enhances targeting precision—focusing radiation on the tumor while minimizing exposure to healthy brain tissue and surrounding critical structures. The result is not only safer treatment, but also a better chance at preserving cognitive function for patients.
“With ZAP-X, radiation oncology centers can expand their radiosurgery programs without the need for expensive infrastructure upgrades,” Dr. Adler explained. “That means existing radiotherapy equipment can stay focused on conventional treatments, improving workflow across the board. And because ZAP-X dramatically reduces ambient radiation, it opens the door for repeat treatments in the future—especially valuable as patients live longer thanks to advances in cancer therapy.”
Throughout the conference, Dr. Adler and the ZAP team will host regular booth presentations and live demonstrations, providing attendees with an up-close look at how the ZAP-X platform is reshaping the radiosurgery landscape. These sessions will offer valuable insights into how this technology makes world-class cranial SRS more accessible—whether in major cities or remote care settings.
The introduction of ZAP-X and ZAP-Axon at ESTRO reflects the company’s mission to break down barriers in radiosurgery, both technologically and geographically. As healthcare systems across the globe face growing demand for advanced brain cancer treatment, the need for efficient, scalable solutions is more critical than ever.
Note: The ZAP-Axon Radiosurgery Planning System is currently pending U.S. FDA 510(k) clearance and CE mark approval in the European Union.
About ZAP Surgical Systems, Inc.
Founded in 2014 by Dr. John R. Adler, a pioneer in radiosurgery and inventor of the CyberKnife® system, ZAP Surgical Systems designs and manufactures the ZAP-X® Gyroscopic Radiosurgery® platform. Headquartered in San Carlos, California, the company aims to revolutionize non-invasive brain surgery with its advanced, cost-efficient, and patient-focused solutions. ZAP-X features a self-shielded, vault-free design and incorporates a state-of-the-art linear accelerator, eliminating the need for radioactive isotopes like Cobalt-60.
With its mission to make cutting-edge radiosurgery accessible around the world, ZAP Surgical continues to push the boundaries of innovation in brain tumor treatment.
