Seismic Therapeutic Announces Presentation of Preclinical Data Demonstrating Advances in Novel Biologics Discovery at the PEGS Boston Summit

Seismic Therapeutic, Inc., the machine learning immunology company, today announced the presentation of preclinical data that describe the application of the company’s IMPACT platform at PEGS Boston 2023, taking place on May 15-19. The three poster presentations outline how Seismic’s IMPACT platform enables the parallel optimization of multiple parameters, including predicting and removing B and T cell epitopes, augmenting drug-like properties and retaining protein function, to create novel drug candidates across the immunoglobin (Ig) sculpting enzymes and dual-cell bidirectional (DcB) antibody product areas. Seismic is designing novel biologics derived from the IMPACT platform to address unmet medical needs for diseases involving humoral immunity and cell-mediated immunity, the two arms of the adaptive immune system.

“We are pleased to share the advancements of our efforts in biologics discovery uniquely enabled by our IMPACT platform”

“We are pleased to share the advancements of our efforts in biologics discovery uniquely enabled by our IMPACT platform,” said Nathan Higginson-Scott, PhD, Chief Technology Officer and Senior VP Drug Creationof Seismic Therapeutic. “With our parallelized processes we can bypass the trial and error methods of conventional biologics development, enabling simultaneous optimization for biologic function, reduced immunogenicity and augmented developability, resulting in the creation of novel enzyme and antibody therapeutics for the treatment of autoimmune diseases.”

Details of the poster presentations at PEGS Boston 2023 are as follows:

Development and deimmunization of protein therapeutics by machine learning
Session C1C: Machine Learning Approaches for Protein Engineering
Poster number: P212
Author: Nathan Rollins, PhD

Identifying Ig selective proteases for treatment of autoimmune disease using the IMPACT platform
Session C6C: Characterization for Novel Biotherapeutics
Poster number: P211
Author: Jung-Eun (June) Shin, PhD

Discovery and characterization of FcγRIIb specific mAbs
Session C1B: Engineering Antibodies
Poster number: P213
Author: Elliott Wittenberg, BS

About Immunoglobulin (Ig) Sculpting Programs

Seismic’s Ig sculpting enzymes address dysregulated humoral immunity by reducing both Ig levels and antibody effector functions, which contribute to the pathogenesis of a wide range of autoimmune diseases, such as myasthenia gravis, chronic inflammatory demyelinating polyneuropathy and immune thrombocytopenia. Enzymes that specifically cleave antibodies may eliminate circulating and immune-complexed Ig, as well as cell surface B cell receptors, thereby modulating Ig-mediated autoimmunity and inflammation.

About Dual-cell Bidirectional (DcB) Programs

Seismic’s DcB antibody approach targets dysregulated cell-mediated immunity by optimally engaging both T cells and antigen presenting cells, such as B cells, to restore homeostasis. Activating these pathways may control multiple diseases, such as multiple sclerosis, lupus and rheumatoid arthritis. DcB antibodies simultaneously engage multiple inhibitory pathways in more than one immune cell type thereby targeting and regulating both sides of the immune synapse.


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