Pyx Health Secures No. 661 Spot on 2025 Inc. 5000 List, Marking Fourth Consecutive Year Among America’s Fastest-Growing Private Companies
In its highly anticipated annual ranking of the fastest-growing private companies in the United States, Inc. magazine has once again recognized Pyx Health as one of the country’s leading innovators and growth drivers. The 2025 Inc. 5000 list places Pyx Health at No. 661, a distinction that marks the company’s fourth consecutive appearance on this prestigious roster.
The Inc. 5000 is widely regarded as a definitive snapshot of entrepreneurial success in the American economy. It highlights independent and privately held businesses that are achieving exceptional growth despite economic uncertainty, competitive markets, and changing industry landscapes. Over the years, the list has featured some of the world’s most recognized brands—Microsoft, Meta (formerly Facebook), Chobani, Under Armour, and Timberland—each of which earned a spot before reaching global prominence.
A Mission-Driven Company with Deep Healthcare Impact
Founded in 2017, Pyx Health has quickly emerged as a leader in member activation—an area of healthcare focused on motivating and empowering individuals to engage in their own care journey. The company specializes in improving quality outcomes for health plans and their members by combining personalized technology, real human connection, and home-delivered resources to support better health and well-being.
Pyx Health’s platform is designed to identify and address non-medical drivers of health (NMDoH)—critical but often overlooked factors that affect patient outcomes. These can include transportation challenges that prevent members from attending medical appointments, food insecurity that impacts nutrition and chronic condition management, or social isolation that contributes to both mental and physical health decline.
Through this comprehensive approach, Pyx helps close care gaps, improves health outcomes, and reduces overall healthcare spending. The company’s solutions are particularly impactful among Centers for Medicare & Medicaid Services (CMS) populations, where social and economic barriers to care are prevalent.
Strategic Growth Through Acquisitions and Expansion
Pyx Health’s recognition on the Inc. 5000 list is the result of consistent, purposeful growth. Since late 2023, the company has undertaken strategic acquisitions to expand both its capabilities and its reach.
One major milestone was the acquisition of InquisitHealth, a chronic disease management platform. This move strengthened Pyx’s ability to provide tech-enabled, personalized support to individuals managing complex health conditions. By integrating InquisitHealth’s disease-specific expertise into its platform, Pyx enhanced its ability to deliver data-driven insights, proactive interventions, and sustained engagement for high-risk populations.
More recently, Pyx Health acquired FarmboxRx, a food-as-engagement company that delivers healthy, fresh food to individuals as part of their healthcare plan benefits. This acquisition represents a natural extension of Pyx’s mission to address NMDoH, particularly food insecurity—a challenge that disproportionately affects low-income and medically underserved communities.
In the months leading up to these acquisitions, Pyx Health’s co-founders Cindy Jordan and Anne Jordan secured $47.5 million in funding to support the company’s ambitious expansion plans. The combined capabilities of Pyx Health, InquisitHealth, and FarmboxRx allow the company to go far beyond its origins as a loneliness intervention provider, creating a comprehensive, multi-pronged approach to tackling social determinants of health.
A Fourth Consecutive Recognition from Inc. Magazine
CEO and Co-Founder Cindy Jordan expressed deep pride in the company’s achievement, emphasizing that this recognition is not simply a reflection of revenue growth—it is also a validation of Pyx Health’s mission and impact.
“Being named in the Inc. 5000 for the fourth consecutive year is a powerful validation of not just our growth, but of our mission to address NMDoH and expand access to care for underserved populations,” said Jordan. “At a time when policy changes threaten to strip vital benefits and access to care from society’s most vulnerable populations, our work is more urgent than ever. We’re committed to continuing to meet people where they are, with compassion, technology, and a belief that no one should have to navigate their health alone.
Jordan’s comments highlight a critical challenge facing the healthcare sector: shifts in policy and funding that may reduce access to essential services for vulnerable groups. In this climate, organizations like Pyx Health play an increasingly important role in ensuring that underserved communities receive the support they need to live healthier, more stable lives.
Growth Amid Economic and Industry Challenges
Pyx Health’s 2025 ranking is especially notable given the broader economic and industry conditions. Rising inflation, workforce shortages, and a shifting policy landscape have presented significant hurdles for healthcare companies across the nation. Despite these challenges, Pyx has not only maintained but accelerated its growth trajectory.
Across the top 500 companies on this year’s Inc. 5000 list, the median three-year revenue growth rate was an impressive 1,552 percent, and together these companies have added more than 48,678 jobs to the U.S. economy over the past three years. This collective growth underscores the resilience and innovation that define the companies recognized by Inc.
Inc.’s editor-in-chief, Mike Hofman, noted that achieving a place on the list in 2025 is a testament to perseverance and strategic vision:
Making the Inc. 5000 is always a remarkable achievement, but earning a spot this year speaks volumes about a company’s tenacity and clarity of vision,” Hofman said. “These businesses have thrived amid rising costs, shifting global dynamics, and constant change. They didn’t just weather the storm—they grew through it, and their stories are a powerful reminder that the entrepreneurial spirit is the engine of the U.S. economy.
Celebrating Entrepreneurial Excellence
The Inc. 5000 recognition extends beyond a published ranking. Each year, the honorees are invited to celebrate their accomplishments at the Inc. 5000 Conference & Gala, an event that combines networking, thought leadership, and celebration. The 2025 conference will take place October 22–24 in Phoenix, Arizona, bringing together founders, executives, and innovators from across industries.
While all 5,000 companies are recognized, only the top 500 earn a feature in the Fall issue of Inc. magazine, giving them an additional platform to share their story and attract potential partners, clients, and investors.
