GE HealthCare and Mayo Clinic Launch GEMINI-RT to Redefine Personalized Radiation Therapy with AI and Advanced Imaging
Mayo Clinic have announced the launch of a groundbreaking strategic collaboration known as the GE HealthCare–Mayo Clinic Initiative in Radiation Therapy (GEMINI-RT). This ambitious research and innovation partnership is designed to transform the future of personalized radiation therapy and advance cancer care by integrating advanced imaging, artificial intelligence (AI), automation, and continuous patient monitoring across the entire cancer care continuum.
Building on decades of clinical and technological collaboration—and further strengthening a Strategic Radiology Research Collaboration first established in 2023—GEMINI-RT represents a bold step forward in redefining how radiation oncology is planned, delivered, and monitored. The initiative seeks to improve patient outcomes, enhance clinical decision-making, reduce clinician workload, and accelerate the pace of innovation in cancer treatment.
A New Vision for Radiation Oncology
Radiation therapy remains one of the most widely used and effective treatments for cancer worldwide. More than 50% of all cancer patients receive radiation therapy at some point in their care, with over two million patients treated annually in the United States alone. As global cancer incidence continues to rise—reaching 19.3 million new cases in 2022—the demand for more precise, efficient, and personalized radiation therapy solutions has never been greater.
Through GEMINI-RT, GE HealthCare and Mayo Clinic aim to make personalized radiation therapy more accessible by unifying advanced imaging, treatment planning, dosimetry, and real-time patient monitoring into a seamless, data-driven ecosystem. By leveraging Mayo Clinic’s world-class clinical expertise, research infrastructure, and outcomes data alongside GE HealthCare’s strength in medical imaging, engineering, and digital health technologies, the collaboration is positioned to accelerate a new era of precision cancer treatment.
Twinning the Patient, Personalizing the Beam
At the heart of GEMINI-RT is a transformative concept described as “twinning the patient, personalizing the beam.” This approach envisions the creation of highly accurate digital representations—or “digital twins”—of individual patients. These models integrate imaging, clinical data, biological markers, and treatment response patterns to simulate how tumors and healthy tissues may respond to radiation.
GEMINI-RT is grounded in the concept of ‘twinning the patient, personalizing the beam’—a transformative approach made possible by Mayo Clinic’s extensive clinical expertise and outcomes data,” said Bryan Traughber, M.D., Vice Chair of Innovation for Radiation Oncology at Mayo Clinic. “The combination of research and technological acumen could allow us to model individual patient journeys with precision, enabling radiation therapy treatments that are truly tailored to each patient.”
By shifting from generalized treatment protocols to patient-specific modeling, clinicians may be able to optimize radiation dose, timing, and delivery with unprecedented accuracy—maximizing tumor control while minimizing damage to surrounding healthy tissue.
Four Strategic Pillars Driving GEMINI-RT
The GEMINI-RT initiative is structured around four core pillars that collectively aim to transform every stage of radiation oncology—from treatment planning to long-term patient monitoring:
1. Automation
Automation will focus on deploying AI-powered solutions to eliminate repetitive, time-consuming tasks involved in treatment planning and quality assurance. These solutions aim to reduce manual workloads, minimize errors, and accelerate the time from diagnosis to therapy.
Automation also has the potential to improve standardization in radiation oncology, allowing clinicians to dedicate more time to patient care while maintaining high precision and safety standards.
2. Predictive Oncology
Predictive oncology leverages large-scale clinical data, imaging, and AI models to anticipate how patients will respond to specific radiation treatments. By integrating Mayo Clinic’s clinical outcomes data with advanced analytics, the collaboration aims to refine treatment decisions and personalize therapeutic strategies.
This approach may allow oncologists to predict side effects, tumor response, and long-term outcomes earlier in the treatment process—enabling more informed and proactive care planning.
3. Multi-Modal Therapies
Cancer care is increasingly moving toward combination therapies, and GEMINI-RT is exploring how radiation therapy can be effectively paired with emerging treatments such as targeted drugs, immunotherapy, and precision heating technologies.
By combining radiation with novel therapeutic modalities, clinicians may be able to enhance tumor destruction while optimizing safety and treatment efficiency. These multi-modal approaches could be especially impactful in managing aggressive, treatment-resistant cancers.
4. Connected Care
Connected care extends radiation oncology beyond the clinic using AI, biomarkers, sensors, and remote patient monitoring technologies. The goal is to continuously track patient health during and after treatment, enabling the early detection of side effects and complications.
This pillar also supports the growing trend toward outpatient and home-based cancer care—empowering patients with real-time insights while providing clinicians with continuous visibility into patient well-being.
Enhancing the Clinician Experience and Reducing Burnout
Clinician burnout has become a critical challenge in healthcare, particularly in high-demand specialties such as oncology. Heavy administrative workloads, complex treatment planning, and the need for constant coordination across care teams contribute to rising stress levels among clinicians.
According to Dr. Ben Newton, Global Head of Oncology at GE HealthCare, GEMINI-RT is designed with both patients and providers in mind.
“This effort enables us to collaborate on solutions that are not only leading-edge but also clinically meaningful, helping shape the future of personalized radiation therapy,” Dr. Newton said. “By integrating innovative technology and AI across the care continuum, we can improve clinician experience, support high-quality patient care, and help reduce burnout among care teams.”
By automating routine tasks, streamlining workflows, and improving interoperability across oncology systems, GEMINI-RT aims to give clinicians more time for direct patient engagement and complex clinical decision-making.
A Research Powerhouse Based at Mayo Clinic
The research and innovation efforts for GEMINI-RT will be headquartered at Mayo Clinic’s campus in Rochester, Minnesota. This location provides direct access to one of the world’s most advanced clinical environments, enabling real-world validation of new technologies and workflows.
The collaboration will bring together radiation oncologists, medical physicists, engineers, data scientists, and software developers from both organizations. Their collective efforts will focus on rapidly translating research discoveries into clinically deployable solutions.
This initiative also expands upon the 2023 Strategic Radiology Research Alliance between GE HealthCare and Mayo Clinic. Under that earlier agreement, the organizations have already been collaborating on projects involving:
- Advanced Magnetic Resonance (MR) technologies
- Theranostics for cancer treatment
- Diagnostic and interventional ultrasound innovation
GEMINI-RT now builds on that foundation with a dedicated focus on radiation oncology.
Addressing the Growing Global Cancer Burden
With cancer incidence continuing to rise worldwide, the healthcare system faces mounting pressure to deliver high-quality, cost-effective, and scalable cancer treatments. Radiation therapy is a cornerstone of cancer care, but its complexity demands constant technological advancement.
The GEMINI-RT initiative aims to respond to this growing burden by:
- Improving treatment efficiency through automation
- Enabling precision medicine with AI-driven personalization
- Expanding access to advanced radiation therapies
- Supporting outpatient and home-based care models
- Enhancing long-term patient monitoring and survivorship care
Together, these goals align with the broader healthcare shift toward value-based care, where outcomes, patient experience, and system efficiency are equally prioritized.
A Long-Term Vision for Personalized Cancer Care
Rather than focusing solely on short-term product development, GEMINI-RT is structured as a long-term innovation ecosystem. The collaboration is expected to generate a continuous pipeline of research projects, technology pilots, and clinical validation studies over the coming years.
Key long-term objectives include:
- Creating scalable AI platforms for radiation oncology
- Developing predictive models that adapt in real time to patient response
- Advancing digital twin technology for precision treatment planning
- Expanding hybrid care models that integrate in-clinic and at-home monitoring
- Training the next generation of clinician-scientists and medical technologists
By combining clinical excellence with engineering innovation, GE HealthCare and Mayo Clinic aim to set new global standards for how radiation therapy is delivered.
About Mayo Clinic
Mayo Clinic is a nonprofit organization committed to innovation in clinical practice, education and research, and providing compassion, expertise and answers to everyone who needs healing.
About GE HealthCare Technologies Inc.
GE HealthCare is a trusted partner and leading global healthcare solutions provider, innovating medical technology, pharmaceutical diagnostics, and integrated, cloud-first AI-enabled solutions, services and data analytics. We aim to make hospitals and health systems more efficient, clinicians more effective, therapies more precise, and patients healthier and happier. Serving patients and providers for more than 125 years, GE HealthCare is advancing personalized, connected and compassionate care, while simplifying the patient’s journey across care pathways. Together, our Imaging, Advanced Visualization Solutions, Patient Care Solutions and Pharmaceutical Diagnostics businesses help improve patient care from screening and diagnosis to therapy and monitoring. We are a $19.7 billion business with approximately 53,000 colleagues working to create a world where healthcare has no limits.
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