Doximity Partners With Wolters Kluwer to Integrate UpToDate Into Doximity Ask, Enhancing AI-Powered Clinical Decision Support
Doximity, a leading digital platform for medical professionals in the United States, has announced a partnership with Wolters Kluwer Health to bring trusted, evidence-based clinical information from UpToDate directly into Doximity Ask, the company’s artificial intelligence-powered clinical decision support tool. The collaboration aims to help healthcare professionals access reliable medical knowledge, strengthen clinical decision-making and find relevant answers more efficiently within their existing workflows.
Under the partnership, clinicians working at health systems that use both Doximity and UpToDate are expected to gain access to answers informed by UpToDate’s extensive collection of 13,000 clinical topics and best-practice guides. The integration is scheduled to become available in the coming weeks, allowing eligible clinicians to view information drawn from UpToDate alongside responses generated by Doximity Ask.
The announcement brings together two established resources in clinical information and digital healthcare technology. Doximity provides digital tools designed for medical professionals, while Wolters Kluwer Health offers clinical decision support resources used by healthcare providers around the world. By combining their capabilities, the companies aim to make trusted clinical guidance more accessible at the point of care.
The partnership comes as healthcare organizations increasingly explore how artificial intelligence can help clinicians navigate complex medical information. Doctors must frequently evaluate symptoms, consider possible diagnoses, assess treatment options and make decisions while working within time constraints. Access to relevant, evidence-based information can support these responsibilities, particularly when a clinical question requires additional context or when available research does not provide a definitive answer.
The integration is designed to bring expert-reviewed medical content into an AI-supported workflow, helping clinicians access additional information without having to leave the tool they are already using.
Bringing Evidence-Based Clinical Knowledge Into AI Workflows
A central objective of the partnership is to connect the conversational accessibility of Doximity Ask with the established clinical knowledge available through UpToDate.
Medical professionals face a continuously expanding body of research, clinical guidelines and medical literature. Although this information can improve healthcare delivery, identifying the most relevant evidence for an individual patient can be challenging, especially during busy clinical sessions.
Doximity Ask is designed to help clinicians obtain answers to medical questions through an AI-powered interface. With UpToDate content incorporated into the experience, clinicians at participating health systems will be able to access additional information based on the resource’s clinical topics and best-practice guidance.
The companies expect the integration to make it easier for clinicians to consult trusted medical information as part of their existing decision-making process.
Instead of relying exclusively on a single AI-generated response, clinicians will be able to see information informed by UpToDate alongside the answer provided by Doximity Ask. This approach is intended to give healthcare professionals another source of clinical context when evaluating a question or considering an appropriate course of action.
The availability of evidence-based guidance within the same workflow may also reduce the need to switch between separate applications or independently search multiple resources. In clinical environments where time is limited, reducing unnecessary navigation can help professionals focus more directly on assessing patient needs.
However, the integration is intended to support clinicians rather than replace their professional judgment. Medical decisions still require consideration of the patient’s symptoms, medical history, examination findings, preferences and other relevant clinical factors.
UpToDate Adds Expert-Reviewed Medical Information
UpToDate is one of the widely used clinical decision support resources globally. Its content is designed to help healthcare professionals make informed decisions by presenting medical knowledge and recommendations in a clinically useful format.
The resource includes approximately 13,000 clinical topics and best-practice guides covering a broad range of medical questions. Its development process draws on the work of thousands of clinical experts who review and update content as medical knowledge evolves.
According to the announcement, UpToDate draws on approximately 7,600 expert clinicians, editors and peer reviewers who regularly review clinical, drug-related and patient-focused content.
This expert involvement is an important element of the partnership because clinical AI systems need reliable information to produce useful responses. AI tools can make medical information easier to access, but the quality and relevance of the underlying knowledge remain critical considerations when clinicians use such systems.
Yaw Fellin, senior vice president and general manager of Clinical Decision Support and Provider Solutions at Wolters Kluwer Health, emphasized the importance of trusted information in clinical AI.
“Trust in clinical AI starts with the intelligence behind the answer. UpToDate combines the latest evidence with expert judgment, peer review, and a rigorous editorial process designed to keep pace with evolving medicine,” Fellin said.
He added that bringing UpToDate into Doximity Ask would give clinicians access to trusted, cited answers within a workflow they already use at the point of care.
The integration is intended to combine AI-assisted access to information with a clinical content resource that emphasizes expert review and evidence-based guidance. This can be particularly relevant when clinicians need to evaluate a medical question quickly but still require context they can examine and assess.
Addressing Questions That Research Cannot Fully Answer
One of the challenges in medical decision-making is that scientific research does not provide a direct answer for every clinical situation.
Although medical evidence continues to expand, clinicians regularly encounter patients whose symptoms, medical histories or circumstances do not fit neatly into established research findings. Some questions involve uncommon conditions, multiple interacting health problems or situations in which available studies offer limited guidance.
The announcement references research suggesting that nearly one in four medical questions cannot be answered by available research. In such situations, healthcare professionals may need to combine the available evidence with clinical experience, expert judgment and an understanding of the individual patient’s circumstances.
This gap between published evidence and real-world clinical practice helps explain why access to expert-developed clinical resources remains important.
UpToDate draws on the knowledge and experience of clinicians who contribute to reviewing and maintaining its content. This expertise can help clinicians understand established recommendations, consider relevant clinical factors and identify information that may be useful when the evidence is incomplete.
The Doximity-Wolters Kluwer partnership aims to make that knowledge more accessible within an AI-supported environment.
By displaying UpToDate-informed answers alongside Doximity Ask responses, the integration may help clinicians explore clinical questions from more than one informational perspective. The additional content can provide context for questions that do not have a straightforward answer in the available research.
This does not eliminate uncertainty in medicine. Rather, it offers clinicians another resource to consider when making decisions in situations where evidence may be incomplete or where professional judgment remains essential.
Doximity Leadership Highlights the Value of a Second Opinion
Jeff Tangney, chief executive officer of Doximity, said the partnership would give clinicians access to additional expertise without requiring them to leave their existing workflow.
“Doctors know the value of a second opinion,” Tangney said. “With UpToDate available inside Doximity Ask, they can now get one instantly, from thousands of their peers, without leaving their workflow. Users can have both convenience and confidence.”
The concept of a second opinion is relevant in clinical practice because complex cases may benefit from additional perspectives or a review of alternative explanations and treatment considerations.
Clinicians routinely consult colleagues, reference clinical guidelines and review medical literature when addressing difficult questions. Digital tools can help bring some of these information sources closer to the point of care, potentially reducing the time required to locate relevant guidance.
The integration of UpToDate into Doximity Ask is designed to make this process more convenient by placing additional clinical content within a tool that clinicians already use.
The partnership also reflects a broader effort to incorporate specialized medical knowledge into AI systems rather than treating conversational AI as a standalone source of answers.
For clinicians, the value of such tools depends not only on how quickly they generate responses but also on whether the information is relevant, sufficiently supported and presented in a way that enables careful review.
Access to cited clinical information can help professionals examine the basis of a response and determine whether it applies to the patient they are treating.
Prisma Health Executive Sees Potential to Save Clinicians Time
Nicholas Perkins, DO, MBA, chief clinical analytics officer at Prisma Health, highlighted the practical challenges doctors face when medical research does not directly resolve a clinical question.
“The number of cases for which clinical research has no direct answer would surprise you,” Perkins said. “Clinicians rely on trusted resources like UpToDate to support clinical decision-making when evidence is scarce. The ability to access it right within Doximity Ask has the potential to save doctors time so they can focus on helping patients.”
His comments point to a common challenge in healthcare: clinicians must balance the need to review relevant information with the demands of patient care.
Doctors may need to evaluate multiple sources when considering a complex diagnosis or treatment decision. Searching for information across different systems can add to their workload, particularly when they are seeing patients throughout a busy clinical day.
Integrating trusted clinical content into an existing AI-supported tool could help reduce some of that friction. If clinicians can find relevant guidance more directly, they may spend less time navigating separate information resources.
The potential benefit is not simply faster access to answers. It also involves giving clinicians a convenient way to consult additional evidence and expert guidance while maintaining responsibility for the final clinical decision.
The partnership announcement does not establish a measured reduction in consultation times or demonstrate specific improvements in patient outcomes. Instead, it describes an integration intended to make clinical information more accessible and potentially save clinicians time.
The impact will depend on how the functionality is implemented, how clinicians use the information and whether it fits effectively into real-world healthcare workflows.
Doximity Expands Its Clinical AI Presence
Doximity’s existing reach among U.S. medical professionals provides an important foundation for the partnership.
According to the company, its membership includes more than 85% of all doctors in the United States. Its Clinical AI Suite, which includes Doximity Ask, has been deployed across more than 165 health systems, including 10 of the nation’s top 20 hospitals.
These figures demonstrate the scale of Doximity’s professional network and the presence of its AI tools within healthcare organizations.
The company has been expanding its use of AI to support clinical workflows, with Doximity Ask serving as a tool for answering medical questions. The addition of UpToDate content represents an effort to connect that technology with an established source of clinical decision support.
The partnership also arrives as healthcare providers continue to evaluate how AI tools can fit into existing clinical systems without adding unnecessary complexity.
For health systems, adopting AI-based solutions requires consideration of information quality, usability, clinician trust and the practical implications for care delivery. Tools must support the needs of healthcare professionals while fitting into organizational workflows and clinical responsibilities.
Integrating established clinical content into an existing AI tool may offer a way to address some of these considerations by connecting the AI experience with a resource clinicians already know.
The initial availability described by the companies is focused on health systems that use both Doximity and UpToDate. This means access to the integrated functionality will depend on the participating organization’s existing use of the two services.
Peer Review and Clinical Evaluation Remain Important
Doximity also operates its PeerCheck program, which features more than 12,000 cited physician experts who evaluate and improve Doximity Ask outputs.
The program adds a physician-focused evaluation element to the company’s clinical AI strategy. Medical AI systems must be assessed carefully because an answer that sounds convincing may still omit important details, misinterpret a question or fail to account for the circumstances of a particular patient.
Clinical review and evaluation can help identify areas in which responses need improvement. Combined with access to expert-reviewed content, these processes may support the development of tools that are more useful to healthcare professionals.
In July, Doximity Ask was ranked at the top among U.S. clinical AI models in the NOHARM study conducted by researchers from Stanford and Harvard, according to the company’s announcement.
Such evaluations can provide one perspective on model performance, but individual results should be interpreted in the context of the study’s methodology, scope and evaluation criteria. No single ranking can establish that an AI tool is appropriate for every clinical task or patient population.
The integration of UpToDate content represents another component of Doximity’s approach to clinical AI. It brings together an AI interface, an established medical information resource and a physician-focused output evaluation program.
The ultimate usefulness of these tools will depend on how effectively they provide accurate, relevant information and support clinicians in applying it appropriately.
Wolters Kluwer Strengthens the Digital Reach of UpToDate
For Wolters Kluwer Health, the partnership provides another way to make UpToDate’s clinical knowledge available within digital tools used by healthcare professionals.
Clinical decision support resources are most useful when clinicians can access relevant information at the time they need it. Embedding this information into an AI-supported workflow may help connect expert-developed content with the practical questions doctors encounter during patient care.
The partnership also reflects the changing ways healthcare professionals interact with medical information. Traditional reference resources remain important, but clinicians are increasingly exploring conversational interfaces that allow them to ask questions in natural language and receive focused responses.
Combining these interfaces with evidence-based clinical content may help bridge the gap between the large volume of medical knowledge available and the immediate information needs of clinicians.
At the same time, clinical AI requires careful attention to transparency, reliability and professional oversight. Healthcare professionals need to be able to assess the information presented to them and determine whether it is suitable for the patient and clinical situation.
By bringing UpToDate-informed content into Doximity Ask, the companies aim to make trusted, cited medical information available in a more integrated format.
Partnership Aims to Support More Informed Clinical Decisions
The Doximity and Wolters Kluwer Health partnership brings together AI-powered clinical question answering and a well-established evidence-based medical information resource.
The planned integration will allow clinicians at health systems using both platforms to access information informed by UpToDate’s 13,000 clinical topics and best-practice guides alongside Doximity Ask responses. The companies expect the functionality to become available in the coming weeks following the announcement.
The collaboration is intended to help clinicians find relevant medical guidance more efficiently, consult additional expert knowledge and navigate questions that may not have a direct answer in published research.
For Doximity, the agreement extends the clinical information available through its AI tools and builds on its existing presence across U.S. medical professionals and health systems. For Wolters Kluwer Health, it creates an additional route for clinicians to access UpToDate content within an AI-supported workflow.
As healthcare organizations continue to explore AI-assisted decision support, the partnership highlights the importance of combining technological convenience with credible medical knowledge, expert review and clinical judgment.
The companies’ stated goal is to give doctors easier access to trusted information while helping them make decisions in complex and rapidly changing clinical environments. Although the integration’s real-world impact will depend on implementation and clinician use, the announcement represents another step in the development of AI tools designed to support—not replace—the expertise of healthcare professionals.
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